Namuhla ngifuna ukunethula emsebenzini owenziwe unjiniyela waseMexico uRodrigo Lozano , umfundi weziqu zobudokotela eNyuvesi yaseWollongong (e-Australia) okwazile ukuklama nokukhiqiza esebenzisa ukuphrinta kwe-3D ngaphandle kobuchopho obuncane lapho kufundwa khona ukuziphatha kwama-neurons ezifweni ezithile zobuchopho noma kubantu abasebenzisa izidakamizwa.
Ukuze enze izivivinyo zokuqala kulo msebenzi oyinkimbinkimbi, unjiniyela ngokusobala wanquma ukudala imodeli yobuchopho encane esebenzisa ubuchwepheshe bokuklama nokuphrinta be-3D . Ama-neurons egundane abekwa ezingqimbeni ezahlukene zemodeli, futhi la ma-neurons aphila izinsuku eziyishumi, enza zonke izinqubo zawo zokuxhumana ngaphandle kokulimala.
Bakha ubuchopho obuncane lapho ama-neurons angaphila kuze kube yizinsuku eziyi-10 enza yonke imisebenzi yawo yemvelo.
Njengoba uRodrigo Lozano ngokwakhe echazile :
Ama-neuron e-cortical angakavuthwa avela kumagundane asemathunjini ahlanganiswe ku-hydrogel ye-polymer ebizwa ngokuthi i-gellan gua, edalwe ngokwemvelo futhi evumela ukudalwa kokumiswa kweseli okubizwa ngokuthi ' i-bio-ink '.
Ngokuphathelene nezinto okukhulunywe ngazo ngaphambili, kubalulekile ukuqaphela ukuthi zishibhile futhi ziyahambisana nomzimba womuntu ngoba zinezimbobo ezanele ukuvumela izakhamzimba kanye nemikhiqizo engcolile evela emaseli ukuba idlule. Ngaphezu kwalokho, le nto iqina ngempumelelo ekushiseni kwegumbi futhi ingashintshwa ngamakhemikhali ngama-peptide afana ne-RGD.
Okokugcina, kubalulekile ukuqaphela ukuthi ngenxa yesakhiwo esiyisisekelo salobu buchopho obuncane kanye nokusetshenziswa kwale hydrogel entsha , ama-neurons akwazi ukukhula nokwandisa ukuxhumana kwawo kumakhulu ama-micron. Ngenxa yalokho, ngemva kwezinsuku eziyishumi kusukela ekuqaleni kokuhlolwa, kwaqinisekiswa ukuthi isakhiwo sasinezici ezifanayo namaseli e-cortical avuthiwe, nokuthi ama-neurons ayekwazile ukwakha izakhiwo ezinezingqimba ezifana ne-cerebral cortex.